Regulation of Synapse Development by Activity Dependent Transcription in Inhibitory Neurons

Regulation of Synapse Development by Activity Dependent Transcription in Inhibitory Neurons

by Alan Robert Mardinly

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Neuronal activity and subsequent calcium influx activates a signaling cascade that causes transcription factors in the nucleus to rapidly induce an early-response program of gene expression. This early-response program is composed of transcriptional regulators that in turn induce transcription of late-response genes, which are enriched for regulators of synaptic development and plasticity that act locally at the synapse.

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