Characterization of Novel Structure-regulatory Relationships Within Interacting Two-finger Cys2His2 Zinc Finger Protein Motifs

Characterization of Novel Structure-regulatory Relationships Within Interacting Two-finger Cys2His2 Zinc Finger Protein Motifs

169 pages· 2008· ISBN 9780549621263
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The discovery of an unusual interacting Cys2His2 zinc finger motif from Gli1 zf1-2 a decade ago was a significant departure from the classic model of Cys2His2 family zinc finger proteins as independent structural modules. The solution structures of Zap1 zf1-2CA3 and Zic1 zf1-3 reported here provide important new milestones toward the structural and functional characterization of this two-finger motif.

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