Development of Constant-time Correlated Spectroscopy on a 3T Clinical MRI/MRS Scanner

Magnetic Resonance Spectroscopy (MRS) is widely used both as a fundamental research technique, as well as diagnostic tool in medical research providing unique information about the metabolites. In this thesis, we report our work on the development of novel localized constant-time correlated Magnetic Resonance Spectroscopic technique for resolving the overlapping metabolites and also to improve the quantification strategies. The new sequence was implemented on a GE 3T MRI/MRS scanner. The underlying spin dynamics is discussed for a two-spin ½ system with a J coupling. We demonstrate the coherence transfer to cross peaks and diagonal peaks by changing the constant time. Theoretical simulations of the MR spectra for simple spin systems were performed and for our new sequence using GAMMA program. In addition we have also implemented theoretical simulations of one and two-dimensional MRS sequences within GAMMA environment for understanding the effect of field strength on MR spectra and also J modulation.