Mechanisms of the SAGA Coactivator Complex in Regulation of Gene Transcription

Mechanisms of the SAGA Coactivator Complex in Regulation of Gene Transcription

269 pages· 2006· ISBN 9780549868866
About
Spt8, Spt3, and possibly Ada1 SAGA subunits function to regulate interaction with TBP, whereas the Gcn5 bromodomain is required for nucleosomal acetylation of the trimeric Ada3/Ada2/Gcn5 or the SAGA complexes. My results advance our basic understanding of how SAGA regulates gene transcription.

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