The Effects of Tumor Necrosis Factor-alpha (TNF-alpha) on Tight Junction Proteins of the Brain Endothelial Cells

The Effects of Tumor Necrosis Factor-alpha (TNF-alpha) on Tight Junction Proteins of the Brain Endothelial Cells

103 pages· 2008· ISBN 9780549977674
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The blood-brain barrier (BBB) is a specialized system of capillary endothelial cells that is located between the central nervous system and the peripheral circulation. The tight junction (TJ) complex of the BBB is critical for maintaining brain homeostasis and its disruption has been associated with several inflammatory diseases. Previous studies have shown that TNF-alpha elicits increased BBB permeability. This study was designed to investigate the potential cellular mechanisms behind this permeability change.

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