A Multi-dimensional Approach to Study SARS-CoV Replication and Potential Applications

Second, we have affinity matured a pair of different domain targeting binders, N17 and N22, to enhance both the binding affinity and the properties essential for incorporation into a Indium Oxide nanowires field effect transistor based detection platform. Using site directed linkage, these affinity reagents were covalently attached the nanowire. With the derived nanosensor, we have demonstrated the Fn-based binders enable specific and quantitative detection of N protein in the range of 0.6nM to 9.7nM.