Inhibition of Human Embryonic Stem Cell Differentiation by Mechanical Strain

Inhibition of Human Embryonic Stem Cell Differentiation by Mechanical Strain

by Somen Saha

146 pages· 2007· ISBN 9780549377788
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Pharmacologic inhibitors of p38MAPK, MEK and FAK do not repress the mechanical inhibition of hESC differentiation. Wnt activation in presence of MEF-conditioned medium promotes self-renewal in hESCs under strain. These findings imply that application of mechanical forces may be useful, in combination with chemical and matrix-encoded signals, toward controlling differentiation of hESCs for therapeutic applications.

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