Contribution of Non-centrosomal Microtubules to Mitotic Spindle Assembly in Mammalian Cells

Contribution of Non-centrosomal Microtubules to Mitotic Spindle Assembly in Mammalian Cells

110 pages· 2007· ISBN 9780549175711
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One way to explain how a bipolar spindle assembles has been the 'search and capture' model. According to this model, microtubules emanating from centrosomes search the cytoplasm for kinetochores, which capture microtubules laterally. Once captured, the chromosomes move towards the spindle equator, ultimately resulting in a bipolar spindle.

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