Involvement of Inflammation in Tau Pathology and Mechanisms that Drive Neurdegeneration in Alzheimer's Disease

Involvement of Inflammation in Tau Pathology and Mechanisms that Drive Neurdegeneration in Alzheimer's Disease

167 pages· 2008· ISBN 9780549610441
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Two of the hallmarks of neurodegenerative disorders, such as Alzheimer's disease (AD), are (1) the appearance of proteinaceous deposits in inclusion bodies containing aggregates of ubiquitinated proteins and (2) activated microglia and astrocytes surrounding the diseased neurons. In Alzheimer's disease, the intracellular inclusion bodies are known as neurofibrilary tangles (NFT). The mechanisms leading to inclusion body formation and their role in the progression of neurodegeneration are still largely unknown.

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