The Role of Potassium Ion Channels and Redox Potential in the Strain-dependent Response to Hypoxia

The Role of Potassium Ion Channels and Redox Potential in the Strain-dependent Response to Hypoxia

121 pages· 2009· ISBN 9780549983422
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Two strains of mice were identified that possess differing cardiopulmonary responses to hypoxia. CF1 mice acclimated poorly to chronic hypoxia as indicated by right ventricular hypertrophy, decreased PO2, increased [Hb], and increased mortality. All are indicators of a robust constrictive response by the pulmonary artery to hypoxia. CAF 1 mice did not present any of these symptoms, leaving them more able to acclimate to chronic hypoxia. To determine if strain-dependent differences exist at the cellular level, properties of pulmonary artery smooth muscle cells (PASMCs) were investigated. Whole cell patch clamping revealed a strain-dependent difference in K+ current during exposure to either 10%O 2 or 3%O2 bath solution. K+ current (I/Imax) was significantly decreased in the CF1 strain compared to the CAF 1 mice at voltage steps of +60mV (0.567+/-0.378(21%) vs. 0.417+/-0.255(10%) vs. 0.315+/-0.205 (3%); p

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